GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE
GENETIC SUSCEPTIBILITY TO SCLERODERMA-LIKE SYNDROME INDUCED BY VINYL CHLORIDE
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氯乙烯引起的硬皮病样综合征的遗传易感性
DOI：
10.1016/s0140-6736(83)91578-7
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Jones
中科院分区：
文献类型：
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作者：
C. Black;A. Walker;L. Catoggio;K. Welsh;R. Bernstein;A. McGregor;J. Jones
氯乙烯（VC）单体在聚氯乙烯生产过程中可引起部分接触到它的工人患硬皮病样综合征。作为5年随访研究的一部分，在44名工人中检测了HLA a、B和DR抗原以及抗着丝粒和抗硬皮病-70抗体。其中21人患有严重的氯乙烯疾病，23人患有轻度的氯乙烯疾病。50名“典型”硬皮病患者和148名健康的医院工作人员作为对照。21例重症VC患者中有11例DR3阳性，其中8例同时具有B8和DR3抗原。23名轻度疾病患者均未携带这两种抗原。VC病中的hla抗原频率与硬皮病中的相同（DR5频率升高，B8和DR3之间的连锁不平衡增加）。然而，在两种情况下，自身抗体的频率有显著差异。
Vinyl chloride (VC) monomer can induce a scleroderma-like syndrome in a proportion of workers exposed to it during production of polyvinyl chloride. As part of a 5-year follow-up study HLA A, B, and DR antigens and anti-centromere and anti-scleroderma-70 antibodies were determined in 44 such workers. 21 of these had severe and 23 mild forms of vinyl-chloride disease. 50 patients with "classical" scleroderma and 148 healthy hospital workers acted as controls. 11 of the 21 patients classified as having severe VC disease were DR3 positive, and 8 of these had both B8 and DR3 antigens. None of the 23 patients with mild disease carried either antigen. The HLA-antigen frequencies in VC disease mirrored those found in scleroderma (raised DR5 frequency and increased linkage disequilibrium between B8 and DR3). There were, however, significant differences in the frequency of autoantibodies in the two conditions.