Thin unresponsive endometrium-a possible complication of surgical curettage compromising ART outcome
Thin unresponsive endometrium-a possible complication of surgical curettage compromising ART outcome
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DOI：
10.1007/s10815-008-9245-y
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发表时间：
2008-08-01
影响因子：
3.1
通讯作者：
Fatum, Muhammad
中科院分区：
文献类型：
--
作者：
Shufaro, Yoel;Simon, Alex;Fatum, Muhammad
目的子宫内膜厚度对着床有重要意义。很少有数据涉及子宫内膜持续薄的病因。我们提出了一个病人队列，以确定共同的特点，并得出conclusion.Methods 13日的1,405 IVF患者反复薄无反应的子宫内膜（< 7毫米）。年龄，病史，宫腔状况，治疗类型和outcome.Results患者年龄为35.9 +/- 5.7岁。10名患者之前进行过刮宫术。9例患者宫腔及内膜正常，4例粘连被诊断并切除。在99个周期后进行，子宫内膜厚度增加22。49个周期中，11例妊娠。他们的结果是8流产，两个终止由于畸形，和一个livebirth.Conclusions薄无反应的子宫内膜与刮宫，不一定与宫腔粘连。即使最终出现了足够的增厚，生殖结果仍然很差。因此，应该为这些患者寻找其他替代方案。
Purpose Endometrial thickness is important for implantation. Little data addresses the etiology of persistently thin endometrium. We present a patient cohort in order to define common features and draw conclusions.Methods Thirteen out of 1,405 IVF patients repeatedly had thin unresponsive endometrium (< 7 mm). Age, history, uterine cavity status, treatment type and outcome were examined.Results Patient age was 35.9 +/- 5.7 years. Ten patients had a curettage performed previously. Nine patients had normal cavity and endometrium, and in four adhesions were diagnosed and removed. Out of 99 cycles performed afterwards, endometrial thickness increased in 22. ETs were performed in 49 cycles resulting in 11 pregnancies. Their outcome was eight miscarriages, two terminations due to malformations, and one live birth.Conclusions Thin unresponsive endometrium was associated with curettage, not necessarily with intrauterine adhesions. Even if adequate thickening eventually occurred, the reproductive outcome was still very poor. Therefore other alternatives should be sought for these patients.