Synthesis, characterization, and self-assembly behaviors of a biodegradable and anti-clotting poly(EDTA-diol-co-butylene adipate glycol urethanes).
Synthesis, characterization, and self-assembly behaviors of a biodegradable and anti-clotting poly(EDTA-diol-co-butylene adipate glycol urethanes).
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DOI：
10.1039/c4tb00603h
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发表时间：
2014-08
期刊：
影响因子：
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通讯作者：
Lixia Bao;Xin Luo;Dandan Zhang;Jingxin Lei;Qiue Cao;Jiliang Wang
中科院分区：
文献类型：
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作者：
Lixia Bao;Xin Luo;Dandan Zhang;Jingxin Lei;Qiue Cao;Jiliang Wang
以EDTA-2Na和聚乙二醇为原料，通过酯化反应合成了抗凝血的EDTA-二醇。以乙二胺四乙酸二醇和可生物降解的聚己二酸1，4-丁二醇酯（PBA）为软链，1，4-丁二醇（BDO）和二异氰酸酯（HDI）为硬链，合成了具有抗凝血和生物降解性能的多嵌段聚氨酯。通过拉伸试验、热重分析、接触角和吸水率测量以及溶血性测量，研究了软链中EDTA-二醇含量对聚氨酯力学性能、热稳定性、亲水性和抗凝血能力的影响。用荧光光谱和透射电镜研究了所得聚氨酯的自组装行为。所制备的聚氨酯在组织工程、药物载体等生物医用材料领域具有巨大的应用潜力。
Anti-clotting EDTA-diol was successfully synthesized by an esterification reaction between EDTA-2Na and poly(ethylene glycol). Novel anti-clotting and biodegradable multi-block polyurethanes were then prepared by EDTA-diol and biodegradable poly(1,4-butylene adipate glycol) (PBA) as the soft chain, and 1,4-butanediol (BDO) and hexamethylene diisocyanate (HDI) as the hard chain, respectively. The effect of the EDTA-diol content in the soft chain of the prepared polyurethanes on mechanical properties, thermal stability, hydrophilicity, and anticoagulant ability was largely investigated by tensile tests, thermogravimetric analysis, contact angle and water absorption measurements, and hemolytic measurement. Self-assembly behaviors of the resulting polyurethanes were also evaluated by fluorescence spectroscopy and transmission electron microscopy. The prepared polyurethanes have large potential applications in the fields of biomedical materials such as tissue engineering and drug carriers.