Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy
Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy
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DOI：
10.1038/ncomms4702
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发表时间：
2014-05-01
影响因子：
16.6
通讯作者：
Kim, Won Jong
中科院分区：
文献类型：
--
作者：
Namgung, Ran;Lee, Yeong Mi;Kim, Won Jong
通过设计一种靶向给药系统可以实现有效的抗癌治疗，该系统在循环中高度稳定，并能有效地被靶肿瘤细胞摄取。我们报道了一种新型的纳米组装药物传递系统，它是由聚合物-环糊精结合物和聚合物-紫杉醇结合物之间的多价主-客体相互作用形成的。多价包合物为纳米组装提供了高度的稳定性，通过被动和主动靶向机制有效地将紫杉醇输送到靶向癌细胞。紫杉醇和聚合物主链之间的酯键允许紫杉醇通过降解在细胞内有效释放。这种新型的靶向纳米组装在小鼠肿瘤模型中显示出显著的抗肿瘤活性。这项研究建立的策略也为发展先进的抗癌药物输送提供了知识。
Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.