Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD
Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD
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DOI：
10.1681/asn.2007050622
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发表时间：
2008-09-01
影响因子：
13.6
通讯作者：
de Vernejoul, Marie-Christine
中科院分区：
文献类型：
--
作者：
London, Gerard M.;Marchais, Sylvain J.;de Vernejoul, Marie-Christine
在终末期肾病患者中，动脉钙化和骨活性之间存在反比关系。钙超载与动脉钙化有关，而动脉钙化又与动脉硬化有关。骨活性是否与钙负荷、主动脉僵硬或动脉钙化相互作用尚不清楚。本研究评估了骨活性对含钙磷结合剂剂量与主动脉僵硬度（通过脉搏波速度测量）或腹主动脉钙化评分之间关系的影响。主动脉僵硬度和钙化均与钙负荷呈正相关，与骨活性呈负相关。发现含钙磷结合剂的剂量与骨活性之间存在显著的相互作用，因此钙负荷对存在粘连性骨病的主动脉钙化和硬化具有显著更大的影响。不依赖于任何其他因素，包括含钙磷结合剂的剂量，粘附性骨与更大的主动脉硬化相关，表明骨和动脉壁之间的串扰。
An inverse relationship between arterial calcifications and bone activity has been documented in patients with ESRD. Calcium overload is associated with arterial calcification, which is associated with arterial stiffening. Whether bone activity interacts with calcium load, aortic stiffness, or arterial calcification is unknown. This study assessed the impact of bone activity on the relationships between the dosage of calcium-containing phosphate binders and aortic stiffness (measured by pulse wave velocity) or abdominal aorta calcification score. Aortic stiffness and calcification were both positively associated with calcium load and negatively associated with bone activity. A significant interaction was found between dosage of calcium-containing phosphate binders and bone activity such that calcium load had a significantly greater influence on aortic calcifications and stiffening in the presence of adynamic bone disease. Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls.