Role of faecal gas analysis for the diagnosis of IBD.
Role of faecal gas analysis for the diagnosis of IBD.
复制标题
粪便气体分析在 IBD 诊断中的作用。
DOI：
10.1042/bst0391079
复制
发表时间：
2011
影响因子：
3.9
通讯作者：
C. Probert
中科院分区：
文献类型：
--
作者：
C. Probert
IBD（炎症性肠病）的诊断基于对症状和体征的临床评估，并进行一系列检查。所使用的检查通常会让患者感到不愉快；它们具有侵入性、成本高昂且具有潜在危险。患者经常报告说，在 IBD 发作期间，肠胃气或粪便中散发出的气体的气味异常。我们的小组对健康受试者、感染性腹泻患者以及克罗恩病或溃疡性结肠炎复发和缓解患者的粪便样本中排出的顶空气体中的 VOC（挥发性有机化合物）进行了表征。对气相色谱-MS 数据（VOC 分析）的细致分析揭示了与特定传染病和 IBD 密切相关的化合物模式。这些化合物代表疾病状态下微生物区系和/或细菌和/或上皮细胞代谢的变化。这些概况提供了对一系列传染性和非传染性胃肠道疾病进行快速非侵入性评估的潜力。对 VOC 的研究可能有助于更好地了解 IBD 的发病机制。
The diagnosis of IBD (inflammatory bowel disease) is based on the clinical evaluation of symptoms and signs leading to a series of investigations. The investigations used are often unpleasant for patients; they are invasive, costly and potentially dangerous. Patients often report that the odour of flatus, or the gas emitted from faeces, is abnormal during a flare of their IBD. Our group has characterized the VOCs (volatile organic compounds) in the headspace gas emitted from faecal samples from healthy subjects, from patients with infectious diarrhoea and from those with Crohn's disease or ulcerative colitis, both in relapse and remission. Painstaking analysis of gas chromatography-MS data (VOC profiling) has revealed patterns of compounds that are strongly associated with specific infectious diseases and with IBD. These compounds represent a change in the microflora and/or the metabolism of bacteria and/or the epithelium in disease states. These profiles offer a potential for rapid non-invasive assessment of a range of infectious and non-infectious gastrointestinal diseases. The study of VOCs may lead to a better understanding of the pathogenesis of IBD.