Contact heat evoked potentials and habituation measured interictally in migraineurs.
Contact heat evoked potentials and habituation measured interictally in migraineurs.
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DOI：
10.1186/1129-2377-16-1
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发表时间：
2015-01-06
期刊：
影响因子：
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通讯作者：
Marziniak M
中科院分区：
文献类型：
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作者：
Beese LC;Putzer D;Osada N;Evers S;Marziniak M
偏头痛患者在发作之间缺乏对不同诱发电位模式的习惯性。本研究探讨了在无偏头痛间隔期间，通过接触热诱发电位（CHEPs）和定量感觉测试（QST）评估疼痛刺激后的皮质反应。我们招募了22名偏头痛患者和22名健康受试者。在51°C的温度下对脸颊和前臂掌侧进行接触性热刺激后，患者和健康对照组的皮层电位显示A-δ振幅显著降低。当受试者的注意力被吸引到算术任务时，偏头痛患者的振幅习惯性部分缺乏。QST在偏头痛患者和对照组之间没有显示出任何差异。我们的研究结果可以主要被认为是证明患者和健康对照组在执行计算任务时显示出显著较低的振幅。如果不进行计算任务，我们就无法显示偏头痛患者缺乏习惯性。然而，在执行计算任务时，我们的结果部分地表明了这一假设。
A lack of habituation of different evoked potential modalities in migraine patients in-between attacks has been suggested. This study investigates cortical response after painful stimuli evaluated by contact heat evoked potentials (CHEPs) and quantitative sensory testing (QST) during the migraine-free interval. We enrolled 22 migraine patients and 22 healthy subjects. Cortical potentials after contact heat stimulation of the cheeks and the volar forearm at a temperature of 51°C showed significantly reduced A-δ-amplitudes in patients and healthy controls. When the subjects’ attention was drawn to an arithmetic task, a partial lack of habituation of amplitude could be seen in migraine patients. QST did not show any difference between migraineurs and controls. Our findings can be primarily deemed to demonstrate that patients and healthy controls show significantly lower amplitudes while performing the calculation task. Without performing the calculation task we could not show the expected lack of habituation in migraineurs. Yet, while performing the calculation task our results partly suggest that hypothesis.