The effect of ethanol on galactose elimination in rats with normal and choline-deficient fatty livers.
The effect of ethanol on galactose elimination in rats with normal and choline-deficient fatty livers.
复制标题
乙醇对正常和胆碱缺乏脂肪肝大鼠消除半乳糖的影响。
DOI：
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发表时间：
1968
影响因子：
2.1
通讯作者：
A. E. Salaspuro
中科院分区：
文献类型：
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作者：
M. Salaspuro;A. E. Salaspuro
萨拉斯普罗湾P. & Salaspuro，A. E.乙醇对正常和胆碱缺乏性脂肪肝大鼠半乳糖消除的影响。Scand. J. Clin. Lab. Invest. 22，49-53，1968.已经在体内研究了乙醇对肾切除大鼠中半乳糖氧化的抑制作用，并且已经阐明了胆碱缺乏以及饮食中脂肪和碳水化合物含量对半乳糖分解速率的影响，无论是否有乙醇。然而，在患有脂肪肝的胆碱缺乏大鼠中未观察到抑制作用。这一观察结果与低蛋白、胆碱缺乏饮食的脂肪和碳水化合物含量无关。补充胆碱可恢复正常效果，并结合早期对胆碱缺乏性脂肪肝大鼠代谢的研究结果进行了讨论。
Salaspuro, M. P. & Salaspuro, A. E. The Effect of Ethanol on Galactose Elimination in Rats with Normal and Choline-deficient Fatty Livers. Scand. J. clin. Lab. Invest. 22, 49-53, 1968.A study has been made of the ethanol inhibition of galactose oxidation in nephrectomized rats in vivo, and the influence of choline deficiency and the fat and carbohydrate content of the diet on the rate of galactose breakdown, with and without ethanol, has been elucidated.Ethanol induced almost total inhibition of galactose oxidation in normal rats; however, no inhibition was observable in choline-deficient rats with fatty livers. This observation was independent of the fat and carbohydrate content of the low protein, choline-deficient diet. Choline supplementation restored the normal effect.The results are discussed in the light of earlier studies on the metabolism of choline-deficient fatty livers of rats.