Incidence of retinoblastoma in children born after in-vitro fertilisation
Incidence of retinoblastoma in children born after in-vitro fertilisation
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DOI：
10.1016/s0140-6736(03)12332-x
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发表时间：
2003-01-25
期刊：
影响因子：
168.9
通讯作者：
van Leeuwen, FE
中科院分区：
文献类型：
--
作者：
Moll, AC;Imhof, SM;van Leeuwen, FE
荷兰每年有3000名妇女接受体外受精(IVF)治疗，研究结果表明，这些妇女的后代患癌症的风险并不高。在2000年11月至2002年2月期间，我们诊断了5例体外受精后出生的视网膜母细胞瘤患者。为了计算疾病的相对风险，我们假设荷兰通过试管受精受孕的儿童比例在1.0%到1.5%之间，我们诊断出的五名患者代表了这段时间荷兰所有的新病例。视网膜母细胞瘤的相对危险度显著升高(分别为7.2[95%可信区间2.4~17.0]和4.9[1.6~11.3]，分别为1%和1.5%)。在一项以人群为基础的研究中，这种可能的视网膜母细胞瘤风险增加的相关性需要得到证实。
Every year, 3000 women in the Netherlands are treated with in-vitro fertilisation (IVF), and results from studies suggest that the offspring of these women do not have a heightened risk of cancer. Between November, 2000, and February, 2002, we diagnosed retinoblastoma in five patients born after IVF. To calculate the relative risk of the disease, we assumed that the proportion of children conceived by IVF in the Netherlands is between 1.0 and 1.5%, and that the five patients who we diagnosed with the disease represent all new cases in the Netherlands during that period. Relative risks for retinoblastoma were significantly raised (7.2 [95% CI 2.4-17.0], and 4.9 [1.6-11.3], for 1% and 1.5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established.