Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients
Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients
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DOI：
10.1016/j.biopsych.2014.10.014
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发表时间：
2015-07-01
影响因子：
10.6
通讯作者：
Miller, Brian J.
中科院分区：
文献类型：
--
作者：
Black, Carmen;Miller, Brian J.
背景：严重的精神障碍与炎症有关。细胞因子和趋化因子水平的异常与精神障碍和自杀行为有关。我们对有和没有自杀倾向的患者和有自杀倾向的患者和健康对照组的细胞因子和趋化因子水平进行了荟萃分析。方法：我们通过搜索MEDLINE、JuncINFO和Thomson Reuters Web of Knowledge数据库以及已确定研究的参考列表来确定文章。结果：18项研究符合研究纳入标准，包括583名自杀患者、315名非自杀患者和845名健康对照受试者。有自杀倾向的患者的血液和死后脑标本中的IL-1β和IL-6水平显著高于无自杀倾向的患者和健康对照组(P均<0.05)。在体外，有自杀倾向的患者的外周血单个核细胞产生的IL-2显著低于无自杀倾向的患者和健康对照组(P<；.01)。自杀者脑脊液中IL-8水平显著低于对照组(p<；0.05)。结论：我们在自杀者的血液、脑脊液和死后脑样本中发现了异常细胞因子水平的证据。IL-1β和IL-6水平与自杀倾向密切相关，这些细胞因子可能有助于区分有自杀倾向和非自杀倾向的患者。需要经过严格设计的纵向研究来进一步评估这些关联。
BACKGROUND: Major psychiatric disorders are associated with inflammation. Aberrant cytokine and chemokine levels have been associated with psychiatric disorders and suicidal behavior. We performed a meta-analysis of cytokine and chemokine levels in patients with versus without suicidality and patients with suicidality versus healthy controls.METHODS: We identified articles by searching MEDLINE, PsycINFO, and Thomson Reuters Web of Knowledge databases and the reference lists of identified studies.RESULTS: Study inclusion criteria were met by 18 studies comprising 583 patients with suicidality, 315 patients without suicidality, and 845 healthy control subjects. Levels of interleukin (IL)-1 beta and IL-6 were significantly increased in blood and postmortem brain samples of patients with suicidality compared with both patients without suicidality and healthy control subjects (p < .05 for each). In vitro IL-2 production by peripheral blood mononuclear cells was significantly decreased in patients with suicidality compared with both patients without suicidality and healthy controls (p < .01 for each). Cerebrospinal fluid levels of IL-8 were significantly decreased in patients with suicidality versus control subjects (p < .05).CONCLUSIONS: We found evidence for aberrant cytokine levels in blood, cerebrospinal fluid, and postmortem brain samples of patients with suicidality. Levels of IL-1 beta and IL-6 were most robustly associated with suicidality, and these cytokines may help distinguish suicidal from nonsuicidal patients. Rigorously designed longitudinal studies are needed to evaluate these associations further.