Stress and the single cell: Intrapopulation diversity is a mechanism to ensure survival upon exposure to stress
Stress and the single cell: Intrapopulation diversity is a mechanism to ensure survival upon exposure to stress
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DOI：
10.1016/s0168-1605(02)00239-8
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发表时间：
2002-09-15
影响因子：
5.4
通讯作者：
Booth, IR
中科院分区：
文献类型：
--
作者：
Booth, IR
我们传统上庆祝细菌在各种环境中生长的能力。随着人们的注意力转向它们的生存，我们对暴露在各种压力下帮助生存的机制的多样性印象深刻。从机制上讲，我们通常通过从条件A到条件B的快速转换所发生的变化来衡量适应性。在这种分析中隐含的是细胞群体在其生物化学和反应性方面的同质性。相反，文献中包含许多关于细菌种群异质性的报道。这种异质性的一个实际重要性是任何种群中的一小部分在暴露于杀死大多数种群的压力下生存的能力。这些生物的起源和特性再次受到关注。这篇简短的综述考虑了细菌种群中产生异质性的一些途径，并表明单个细胞表型的这种固有的短暂多样性是一种生存援助。(C)2002 Elsevier Science B.V.保留所有权利。
We traditionally celebrate the capacity of bacteria for growth in a diverse range of environmental niches. As the attention has switched to their survival, we are no less impressed by the diversity of mechanisms that aid survival upon exposure to a variety of stresses. Mechanistically, we usually measure adaptation by the changes that occur upon rapid transfer from condition A to B. Implicit in such analyses is the homogeneity of the population of cells in terms of their biochemistry and responsiveness. In contrast, the literature contains many reports of heterogeneity within bacterial populations. A practical importance of such heterogeneity is the ability of a small fraction of any population to survive exposure to stresses that kill the majority of the population. The origins and properties of such organisms have been receiving renewed attention. This brief review considers some of the routes by which heterogeneity is generated in bacterial populations and suggests that such inherent transient diversity in phenotype of individual cells is a survival aid. (C) 2002 Elsevier Science B.V. All rights reserved.