Fluoride plus functionalized beta-TCP: a promising combination for robust remineralization.
Fluoride plus functionalized beta-TCP: a promising combination for robust remineralization.
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DOI：
10.1177/0022034512449463
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发表时间：
2012-09-01
影响因子：
--
通讯作者：
Pfarrer, A M
中科院分区：
文献类型：
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作者：
Karlinsey, R L;Pfarrer, A M
经过50多年的临床成功，氟化物成为预防蛀牙的金标准剂。特别是，氟化物的作用促进了唾液驱动的脱矿牙釉质的再矿化，并有益地改变了溶解度。尽管如此，蛀牙仍然是一个问题，解决这个问题的一种方法可能是通过开发新的矿化剂。实验室和临床研究表明，氟化物和功能化β-磷酸三钙（fTCP）的组合相对于氟化物，天然β-TCP或单独的fTCP产生更强，更耐酸的矿物质。与其他似乎依赖于高水平钙和磷酸盐来驱动再矿化的基于钙的方法相比，fTCP是一种低剂量系统，旨在适应现有的局部氟化物制剂。β-TCP与有机和/或无机分子的功能化提供了一种屏障，其防止过早的氟化物-钙相互作用，并在通过常见制剂和程序应用时有助于矿化。虽然需要进行额外的临床研究，但补充fTCP以增强基于氟化物的成核活性，随后通过饮食和唾液钙和磷酸盐驱动再矿化，似乎是一种有前途的方法。
With more than 50 years of clinical success, fluoride serves as the gold standard agent for preventing tooth decay. In particular, the action of fluoride facilitates saliva-driven remineralization of demineralized enamel and alters solubility beneficially. Still, tooth decay remains problematic, and one way to address it may be through the development of new mineralizing agents. Laboratory and clinical studies have demonstrated that the combination of fluoride and functionalized beta-tricalcium phosphate (fTCP) produces stronger, more acid-resistant mineral relative to fluoride, native beta-TCP, or fTCP alone. In contrast to other calcium-based approaches that seem to rely on high levels of calcium and phosphate to drive remineralization, fTCP is a low-dose system designed to fit within existing topical fluoride preparations. The functionalization of beta-TCP with organic and/or inorganic molecules provides a barrier that prevents premature fluoride-calcium interactions and aids in mineralization when applied via common preparations and procedures. While additional clinical studies are warranted, supplementing with fTCP to enhance fluoride-based nucleation activity, with subsequent remineralization driven by dietary and salivary calcium and phosphate, appears to be a promising approach.