A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
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DOI：
10.1016/s1097-2765(00)80345-7
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发表时间：
1999-09-01
期刊：
影响因子：
16
通讯作者：
Mowry, KL
中科院分区：
文献类型：
--
作者：
Cote, CA;Gautreau, D;Mowry, KL
Cytoplasmic localization of mRNA molecules is a powerful mechanism for generating cell polarity. II? vertebrates, one paradigm is localization of Vg1 RNA within the Xenopus oocyte, a process directed by recognition of a localization element within the Vg1 3' UTR. We show that specific base changes within the localization element abolish both localization in vivo and binding in vitro by a single protein, VgRBP60. VgRBP60 is homologous to a human hnRNP protein, hnRNP I, and combined immunolocalization and in situ hybridization demonstrate striking colocalization of hnRNP I and Vg1 RNA within the vegetal cytoplasm of the Xenopus oocyte. These results implicate a novel role in cytoplasmic RNA transport for this family of nuclear RNA-binding proteins.
