Transvection at the eyes absent gene of Drosophila.
Transvection at the eyes absent gene of Drosophila.
复制标题
果蝇眼睛缺失基因的横传。
DOI：
10.1093/genetics/138.4.1171
复制
发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
Benzer,S
中科院分区：
文献类型：
--
作者：
Leiserson,WM;Bonini,NM;Benzer,S
果蝇眼睛缺失(Eya)基因是眼祖细胞存活和分化所必需的。眼睛中基因功能的丧失会导致成人复眼的减少或缺失。Eya等位基因的某些组合经历了部分互补，眼睛的大小得到了显著的恢复。这种相互作用对两个等位基因在基因组中的相对位置很敏感；预测会扰乱eya区域染色体同源物配对的重排会扰乱互补。抑制这种相互作用的10种X射线诱导的重排遵循与破坏双胸复合体和十肢瘫痪基因的转运相同的一般规则。此外，就像这些情况下的横移一样，eya的相互作用依赖于正常Zust函数的存在。在eya发现的横行现象表明，这种类型的横行相互作用可能比人们通常认为的更为普遍。
The Drosophila eyes absent (eya) gene is required for survival and differentiation of eye progenitor cells. Loss of gene function in the eye results in reduction or absence of the adult compound eye. Certain combinations of eya alleles undergo partial complementation, with dramatic restoration of eye size. This interaction is sensitive to the relative positions of the two alleles in the genome; rearrangements predicted to disrupt pairing of chromosomal homologs in the eya region disrupt complementation. Ten X-ray-induced rearrangements that suppress the interaction obey the same general rules as those that disrupt transvection at the bithorax complex and the decapentaplegic gene. Moreover, like transvection in those cases, the interaction at eya depends on the presence of normal zeste function. The discovery of transvection at eya suggests that transvection interactions of this type may be more prevalent than generally thought.