Association of Body Mass Index With Peripheral Arterial Disease in Older Adults
Association of Body Mass Index With Peripheral Arterial Disease in Older Adults
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DOI：
10.1093/aje/kwr228
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发表时间：
2011-11-01
影响因子：
5
通讯作者：
Siscovick, David S.
中科院分区：
文献类型：
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作者：
Ix, Joachim H.;Biggs, Mary L.;Siscovick, David S.
作者假设，在先前的研究中，身体质量指数（BMI;体重（kg）/身高（m）（2））与外周动脉疾病（PAD）之间缺乏横截面关联，这可能反映了吸烟或健康状况不佳的人体重较低。他们在美国4个社区的5,419名年龄≥ 65岁的非住院居民中进行了一项观察性研究（1989-1990或1992-1993）。测量踝臂指数，参与者报告他们的PAD手术史。对参与者进行纵向随访，以了解裁定的事件PAD事件。基线时，平均BMI为26.6（标准差为4.6），776名参与者（14%）患有PAD。在截至2007年6月30日的13.2（中位数）年随访期间，发生了276起PAD事件。在横断面分析中，BMI每增加5个单位与PAD呈负相关（患病率（PR）= 0.92，95%置信区间（CI）：0.85，1.00）。然而，在身体健康的人谁从来没有吸烟，协会的方向是相反的（PR = 1.20，95% CI：0.94，1.52）。在健康状况良好的从不吸烟者中，使用50岁时体重计算的BMI与PAD患病率之间（PR = 1.30，95% CI：1.11，1.51）以及基线BMI与随访期间发生的PAD事件之间（风险比= 1.32，95% CI：1.00，1.76）观察到相似的结果。在保持健康且从不吸烟的老年人中，更大的BMI与PAD相关。维持正常体重可降低老年人PAD的发病率和相关合并症。
The authors hypothesized that the absence of cross-sectional associations of body mass index (BMI; weight (kg)/height (m)(2)) with peripheral arterial disease (PAD) in prior studies may reflect lower weight among persons who smoke or have poor health status. They conducted an observational study among 5,419 noninstitutionalized residents of 4 US communities aged >= 65 years at baseline (1989-1990 or 1992-1993). Ankle brachial index was measured, and participants reported their history of PAD procedures. Participants were followed longitudinally for adjudicated incident PAD events. At baseline, mean BMI was 26.6 (standard deviation, 4.6), and 776 participants (14%) had prevalent PAD. During 13.2 (median) years of follow-up through June 30, 2007, 276 incident PAD events occurred. In cross-sectional analysis, each 5-unit increase in BMI was inversely associated with PAD (prevalence ratio (PR) = 0.92, 95% confidence interval (CI): 0.85, 1.00). However, among persons in good health who had never smoked, the direction of association was opposite (PR = 1.20, 95% CI: 0.94, 1.52). Similar results were observed between BMI calculated using weight at age 50 years and PAD prevalence (PR = 1.30, 95% CI: 1.11, 1.51) and between BMI at baseline and incident PAD events occurring during follow-up (hazard ratio = 1.32, 95% CI: 1.00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age.