Effect of antihistamine-antiserotonin and ganglionic blocking agents upon increased capillary permeability following burn trauma.
Effect of antihistamine-antiserotonin and ganglionic blocking agents upon increased capillary permeability following burn trauma.
复制标题
抗组胺抗血清素和神经节阻断剂对烧伤后毛细血管通透性增加的影响。
DOI：
10.1097/00006534-197808000-00093
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Linares
中科院分区：
文献类型：
--
作者：
H. F. Carvajal;B. Brouhard;H. Linares
豚鼠的微小（0.2% TBS），部分厚度，非接触辐射热烧伤在3小时内导致损伤部位明显水肿形成和蛋白质渗漏。远离烧伤部位的皮肤也显示出水分含量的增加，但没有蛋白质泄漏。用盐酸氯异旦明或甲塞吉特与氯苯那敏的混合物对动物进行预处理，可显著减少烧伤后水肿形成和蛋白质渗漏。液体乳剂放射自显像显示蛋白质渗漏主要发生在靠近肉环的皮肤区域。研究表明：烧伤引起的血管通透性增加是体液介导的；白蛋白渗漏仅限于损伤组织；组胺，血清素，可能还有儿茶酚胺在这一现象的发展中起着重要作用。
Tiny (0.2% TBS), partial thickness, non-contact radiant heat burns in guinea pigs resulted, within 3 hours, in significant edema formation and protein leakage at the site of the injury. Areas of skin distant to the burn also showed an increase in water content but no protein leakage. Pretreatment of the animals with either chlorisondamine hydrochloride or a mixture of methysergide and chlorpheniramine significantly decreased postburn edema formation and protein leakage. Liquid emulsion autoradiography revealed that leakage of protein occurs primarily in the areas of skin adjacent to the panniculus carnosus. The studies suggest that: the increase in vascular permeability that occurs as a consequence of burn injuries is humorally mediated; albumin leakage is limited to the injured tissues; and histamine, serotonin, and presumably catecholamines play significant roles in the development of this phenomenon.