Validation of a dose deposited by low-energy photons using GATE/GEANT4
Validation of a dose deposited by low-energy photons using GATE/GEANT4
复制标题
DOI：
10.1088/0031-9155/53/11/019
复制
发表时间：
2008-06-07
影响因子：
3.5
通讯作者：
Maigne, L.
中科院分区：
文献类型：
--
作者：
Thiam, C. O.;Breton, V.;Maigne, L.
基于Geant4工具包的GATE蒙特卡罗模拟平台现已成为模拟PET和SPECT成像设备的普及工具。在这篇文章中，我们探讨了它与用于治疗前列腺癌的低能量(125)I光子近距离照射源的剂量学的相关性。为此，对前列腺癌近距离放射治疗中广泛使用的三种125碘来源进行了模拟。在液态水中进行了再现剂量学参考观测值的门模拟，如径向剂量函数g(R)、各向异性函数F(r，theta)和剂量率常数(Lambda)。计算在EGEE网格基础设施上进行拆分，以减少模拟的计算时间。将结果与其他相关的蒙特卡罗结果以及AAPM工作组43公布和确定的推荐值进行了比较。GATE的结果与AAPM课题组43发表的共识值吻合，精度优于2%，表明GATE是研究低能光子剂量的相关工具。
The GATE Monte Carlo simulation platform based on the Geant4 toolkit has now become a diffused tool for simulating PET and SPECT imaging devices. In this paper, we explore its relevance for dosimetry of low-energy (125)I photon brachytherapy sources used to treat prostate cancers. To that end, three 125-iodine sources widely used in prostate cancer brachytherapy treatment have been modelled. GATE simulations reproducing dosimetric reference observables such as radial dose function g(r), anisotropy function F(r,theta) and dose-rate constant (Lambda) were performed in liquid water. The calculations were splitted on the EGEE grid infrastructure to reduce the computing time of the simulations. The results were compared to other relevant Monte Carlo results and to measurements published and fixed as recommended values by the AAPM Task Group 43. GATE results agree with consensus values published by AAPM Task Group 43 with an accuracy better than 2%, demonstrating that GATE is a relevant tool for the study of the dose induced by low-energy photons.