Association of Nonalcoholic Fatty Liver Disease With Components of Metabolic Syndrome According to Body Mass Index in Korean Adults
Association of Nonalcoholic Fatty Liver Disease With Components of Metabolic Syndrome According to Body Mass Index in Korean Adults
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DOI：
10.1038/ajg.2012.314
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发表时间：
2012-12-01
影响因子：
9.8
通讯作者：
Chung, Goh Eun
中科院分区：
文献类型：
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作者：
Kwon, Young-Min;Oh, Seung-Won;Chung, Goh Eun
目的：非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的原因，其患病率在肥胖个体中要高得多。NAFLD与代谢综合征（MetS）密切相关;然而，关于NAFLD与MetS之间关系的大多数概念都强调肥胖，尽管NAFLD在非肥胖人群中并不罕见。在本研究中，我们的目的是确定非酒精性脂肪肝和代谢综合征之间的关联，并比较这种关联之间的非肥胖和肥胖individual.METHODS：共29,994名成年人进行常规的综合健康评估，包括腹部超声检查，被选中。我们根据非肥胖和肥胖患者的NAFLD计算MetS组分（高血压（BP）、空腹血糖受损、低高密度脂蛋白胆固醇（HDL-C）和高甘油三酯（TG））的校正患病率（PR）。在肥胖和非肥胖受试者中，NAFLD与MetS的大多数组分相关。然而，非肥胖NAFLD患者的代谢综合征某些成分的PR显著高于肥胖患者，尤其是女性。调整后PR非肥胖妇女与肥胖妇女代谢综合征各组分的95%可信区间如下：（1）高血压：1.41（1.31-1.51）vs. 1.05（0.89-1.22）（2）空腹血糖受损：2.04（1.95-2.75）vs. 1.37（1.21-1.53）（3）低HDL-C：2.00（1.92-2.08）vs. 1.40（1.26-1.55），（4）高TG：3.36（3.24-3.47）vs. 1.97（1.76-2.17）.结论：非酒精性脂肪性肝病与代谢综合征各组分的风险相关，非肥胖者的相关性强于肥胖者，尤其是女性。因此，NAFLD应该被认为是非肥胖人群中代谢性疾病的一个有意义的预测因子。
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, and its prevalence is much higher in obese individuals. NAFLD is closely related to metabolic syndrome (MetS); however, most concepts about the relationship between NAFLD and MetS have emphasized obesity, although NAFLD is not a rare disease in the non-obese population. In the present study, we aim to determine the association between NAFLD and MetS and to compare this association between non-obese and obese individuals.METHODS: A total of 29,994 adults who underwent routine comprehensive health evaluations, including abdominal ultrasonography, were selected. We calculated the adjusted prevalence ratios (PRs) for components of MetS (high blood pressure (BP), impaired fasting glucose, low high-density lipoprotein cholesterol (HDL-C), and high triglycerides (TG)) according to NAFLD in non-obese and obese patients.RESULTS: NAFLD was found in 12.6% of non-obese subjects and 50.1% of obese subjects. NAFLD was associated with most components of MetS in both obese and non-obese subjects. However, nonobese NAFLD patients had significantly higher PRs for certain components of MetS than did obese patients, especially among women. Adjusted PRs (95% confidence interval) for components of MetS in non-obese women vs. obese women were as follows: (1) high BP: 1.41 (1.31-1.51) vs. 1.05 (0.89-1.22) (2) impaired fasting glucose: 2.04 (1.95-2.75) vs. 1.37 (1.21-1.53) (3) low HDL-C: 2.00 (1.92-2.08) vs. 1.40 (1.26-1.55), and (4) high TG: 3.36 (3.24-3.47) vs. 1.97 (1.76-2.17).CONCLUSIONS: NAFLD was associated with risk for components of MetS, and the association was stronger in non-obese than in obese individuals, especially in women. Therefore, NAFLD should be considered a meaningful predictor of metabolic diseases in the non-obese population.