Meta-analysis on the G-308A tumor necrosis factor α gene variant and phenotypes associated with the metabolic syndrome
Meta-analysis on the G-308A tumor necrosis factor α gene variant and phenotypes associated with the metabolic syndrome
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DOI：
10.1038/oby.2005.263
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发表时间：
2005-12-01
期刊：
影响因子：
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通讯作者：
Pirola, CJ
中科院分区：
文献类型：
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作者：
Sookoian, SC;González, C;Pirola, CJ
目的：G-308A 肿瘤坏死因子 (TNF) α 基因变异与肥胖、胰岛素抵抗和高血压有关。我们通过荟萃分析对文献进行了系统回顾，以评估 G-308A TNF α 多态性与代谢综合征各组成部分的关联。 研究方法和程序：通过检索文献中使用以下术语的报告来确定研究：糖尿病、胰岛素抵抗、高血压、肥胖或代谢综合征和 TNF、变体或多态性或等位基因以及 Nco 或 -308。从 824 份报告中，我们纳入了 31 项观察性研究、病例对照和基线队列，分析了 TNF α 多态性与代谢综合征的一种或多种成分之间的关联。使用固定效应模型来汇集各个研究的数据。结果：肥胖[比值比，1.23；比值比，1.23； 95% 置信区间 (CI)，1.045 至 1.45； p=0.013] 在来自八项同质研究的总共 3562 名个体中，动脉收缩压（标准化差值，0.132；95% CI，0.016 至 0.25；p
Objective: The G-308A tumor necrosis factor (TNF) alpha gene variant has been associated with obesity, insulin resistance, and hypertension. We performed a systematical review of the literature by means of a meta-analysis to assess the association of the G-308A TNF alpha polymorphism with the components of the metabolic syndrome.Research Methods and Procedures: Studies were identified by searches of the literature for reports using the terms: diabetes, insulin resistance, hypertension, obesity or metabolic syndrome and TNF, variants or polymorphism or alleles, and Nco or -308. From 824 reports, we included 31 observational studies, case control and cohort at baseline, which analyzed the association between the TNF alpha polymorphism and one or more components of the metabolic syndrome. A fixed effect model was used to pool data from individual studies.Results: Obesity [odds ratio, 1.23; 95% confidence interval (CI), 1.045 to 1.45; p=0.013] in a total of 3562 individuals from eight homogeneous studies, systolic arterial blood pressure (standardized difference, 0.132; 95% CI, 0.016 to 0.25; p