Intrinsic collaterals of layer 6 Meynert cells and functional columns in primate V1
Intrinsic collaterals of layer 6 Meynert cells and functional columns in primate V1
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DOI：
10.1016/s0306-4522(03)00429-9
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Rockland, KS
中科院分区：
文献类型：
--
作者：
Li, H;Fukuda, M;Rockland, KS
Meynert细胞是一种独特类型的大神经元，其投射到MT/V5区和皮质下靶点，包括上级丘。最近显示它们具有广泛的内在侧枝，在区域V1的第6层内扩展至8.0 mm [J Comp Neurol 441（2001）134]。本研究采用内源性信号成像结合示踪剂注射，探讨如何映射Meynert细胞侧支与猕猴V1区的功能结构。特别是，我们研究了单个轴突段的终止是否对同眼或对眼域具有选择性。分析39个顺行标记的轴突段（来自四个半球的六个注射部位）表明，终末段跨越几对眼优势柱（ODC），并接触左眼和右眼ODC，对侧眼略有偏差。这与先前报道的第3层锥体神经元的固有侧枝的同眼偏倚形成对比。这表明Meynert固有侧支系统在视野的广泛区域内参与了双眼的相互作用。这可能与光流等过程有关，特别是在宽视场范围内，甚至与轮廓完成或插值有关。(C)2003年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Meynert cells are a distinct type of large neuron which project to area MT/V5 and to subcortical targets, including the superior colliculus. They have recently been shown to have extensive intrinsic collaterals spreading up to 8.0 mm within layer 6 of area V1 [J Comp Neurol 441 (2001) 134]. Using intrinsic signal imaging combined with tracer injections, this study investigates how Meynert cell collaterals are mapped in relation to the functional architecture of area V1 in macaque monkeys. In particular, we examined whether terminations of individual axon segments are selective for same-eye or opposite-eye domains. Analysis of 39 anterogradely labeled axon segments (from six injection sites in four hemispheres) showed that terminal segments cross over several pairs of ocular dominance columns (ODCs) and contact both left- and right-eye ODCs, with a slight bias for the contralateral eye. This contrasts with the same-eye bias previously reported for intrinsic collaterals of pyramidal neurons in layer 3. The suggestion is that the system of Meynert intrinsic collaterals is involved with binocular interactions over wide sectors of the visual field. This might be related to processes such as optic flow or, especially given the wide-field spread, even contour completion or interpolation. (C) 2003 IBRO. Published by Elsevier Ltd. All rights reserved.