Bone Marrow-Derived Stem Cells and Respiratory Disease
Bone Marrow-Derived Stem Cells and Respiratory Disease
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DOI：
10.1378/chest.10-2348
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发表时间：
2011-07-01
期刊：
影响因子：
9.6
通讯作者：
Rankin, Sara M.
中科院分区：
文献类型：
--
作者：
Jones, Carla P.;Rankin, Sara M.
成人骨髓含有大量或离散的祖细胞群，包括内皮、间充质和上皮祖细胞和纤维细胞。在一系列疾病的背景下，据报道内皮祖细胞可以促进血管生成，间充质干细胞是有效的免疫抑制剂，但也可以直接促进组织再生，而纤维细胞已被证明可以诱导组织纤维化。本文概述了这些不同的祖细胞亚群的基本生物学，报告其不同的表型和功能活动。他们的分泌物的差异突出显示，并考虑祖细胞的旁分泌效应与细胞分化的相对作用。本文回顾了有关祖细胞对呼吸系统疾病发病机制的贡献的文献，并讨论了最近使用骨髓祖细胞作为干细胞治疗肺动脉高压、COPD和哮喘的研究。胸部2011; 140（1）：205-211
Adult bone marrow contains a number or discrete populations of progenitor cells, including endothelial, mesenchymal, and epithelial progenitor cells and fibrocytes. In the context of a range of diseases, endothelial progenitor cells have been reported to promote angiogenesis, mesenchymal stem cells are potent immunosuppressors but can also contribute directly to tissue regeneration, and fibrocytes have been shown to induce tissue fibrosis. This article provides an overview of the basic biology of these different subsets of progenitor cells, reporting their distinct phenotypes and functional activities. The differences in their secretomes are highlighted, and the relative role of cellular differentiation vs paracrine effects of progenitor cells is considered. The article reviews the literature examining the contribution of progenitor cells to the pathogenesis of respiratory disease, and discusses recent studies using bone marrow progenitor cells as stem cell therapies in the context of pulmonary hypertension, COPD, and asthma. CHEST 2011; 140(1):205-211