Experimental infection of layer hens with a human isolate of Brachyspira pilosicoli.
Experimental infection of layer hens with a human isolate of Brachyspira pilosicoli.
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用人类分离的毛状短螺旋体对蛋鸡进行实验性感染。
DOI：
10.1099/jmm.0.05040-0
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发表时间：
2003
影响因子：
3
通讯作者：
D. Hampson
中科院分区：
文献类型：
--
作者：
A. Jamshidi;D. Hampson
厌氧肠道螺旋体短螺旋体（Brachyspira pilosicoli）通常定植于许多物种的大肠，包括鸡和人类。本研究的目的是确定从 HIV 感染者腹泻患者体内分离出的毛芽孢杆菌是否能够感染成年鸡并引起疾病。在实验性感染后的 4 周内，一组 8 只接种鸡的粪便含水量持续显着增加（约 6-7%）。八只鸟中的三只的粪便培养呈阳性，并且一直如此。尸检未发现特异性病理变化，盲肠上皮未见螺旋体附着。这些发现证实，毛状芽孢杆菌菌株可以跨越物种屏障进行感染，并在完整的成年鸡中引起慢性轻度腹泻。
The anaerobic intestinal spirochaete Brachyspira pilosicoli commonly colonizes the large intestine of a number of species, including chickens and human beings. The purpose of the current study was to determine whether an isolate of B. pilosicoli recovered from an HIV-infected patient with diarrhoea could infect and cause disease in adult chickens. Over a 4-week period following experimental infection, a group of eight inoculated chickens showed a persistent and significant increase in faecal water content ( approximately 6-7 %). The faeces of three of the eight birds became culture-positive, and remained so. At post-mortem examination, no specific pathological changes were found, and no spirochaetal attachment to the caecal epithelium was observed. These findings confirm that B. pilosicoli strains can infect across species barriers and cause chronic mild diarrhoea in intact adult chickens.