Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression
Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression
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DOI：
10.1016/j.pscychresns.2010.06.008
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发表时间：
2010-10-30
影响因子：
2.3
通讯作者：
Ostergaard, Leif
中科院分区：
文献类型：
--
作者：
Dalby, Rikke Beese;Frandsen, Jesper;Ostergaard, Leif
脑白质病变（WML）被认为在重度抑郁症（MD）的一部分中发挥着重要作用。我们的目的是使用扩散张量成像 (DTI) 和磁化转移成像来描述 WML 对 MD 中白质通路的影响。作为一种新颖的方法，我们使用 DTI 纤维束成像来评估 WML 交叉的通路。我们检查了 22 名迟发性 MD 患者和 22 名年龄和性别匹配的对照者。获得分数各向异性 (FA)、表观扩散系数 (ADC) 和磁化传递比 (MTR) 的参数图来描述组织完整性。在逐个体素的基础上分析抑郁症严重程度和 WML 的束特异性定位之间的关联。我们发现抑郁症严重程度与左上纵束和右钩束中 WML 相交的纤维束之间存在显着正相关。在两组中，WML 的 FA 和 MTR 均显着低于其相交的纤维束和正常白质 (NAWM)，而 ADC 则更高。反过来，WML 相交的纤维束的 FA 明显低于 NAWM，而 ADC 则明显较高。总之，抑郁症的严重程度与 WML 的束特异性定位相关。 WML 对它们相交的通路中的白质完整性有显着影响。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of major depression (MD). We aimed to describe the impact of WMLs on white matter pathways in MD using diffusion tensor imaging (DTI) and magnetization transfer imaging. As a novel approach, we used DTI tractography to assess pathways intersected by WMLs. We examined 22 patients with late-onset MD and 22 age- and gender-matched controls. Parametric maps of fractional anisotropy (FA), apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) were obtained to describe tissue integrity. The association between depression severity and the tract-specific localization of WMLs was analyzed on a voxel-by-voxel basis. We showed a significant positive association between depression severity and fiber tracts intersected by WMLs in the left superior longitudinal fasciculus and the right uncinate fasciculus. In both groups, WMLs had significantly lower FA and MTR, and higher ADC than both the tracts they intersected and the normal-appearing white matter (NAWM). In turn, the tracts intersected by WMLs had significantly lower FA and higher ADC than the NAWM. In conclusion, depression severity correlates with the tract-specific localization of WMLs. WMLs have a pronounced effect on white matter integrity in the pathways they intersect. (C) 2010 Elsevier Ireland Ltd. All rights reserved.