Type 2 diabetes in South Asians: a pathophysiologic focus on the Asian-Indian epidemic.
Type 2 diabetes in South Asians: a pathophysiologic focus on the Asian-Indian epidemic.
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DOI：
10.1007/s11892-004-0026-4
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发表时间：
2004-06-01
影响因子：
4.2
通讯作者：
Banerji, Mary Ann
中科院分区：
文献类型：
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作者：
Bajaj, Mandeep;Banerji, Mary Ann
尽管不存在传统危险因素，但城市和移民亚裔印度人中 2 型糖尿病和冠状动脉疾病的患病率很高。有证据表明，亚裔印度人比白人更容易产生胰岛素抵抗，并且胰岛素抵抗可能在这些疾病的发病机制中发挥重要作用。亚洲印度人的内脏脂肪增加与全身性肥胖增加有关，但这从他们的非肥胖体重指数中并不明显。内脏脂肪增加与血脂异常和胰岛素抵抗频率增加有关，可能是亚洲印度人糖尿病和心血管疾病患病率增加的原因。此外，出生时和一岁时的低体重表明，早期蛋白质能量缺乏可能会导致在以后的生活中容易患上 2 型糖尿病，特别是如果营养的数量和质量方面以及成年期间生活方式的改变构成额外的挑战。
There is a high prevalence of type 2 diabetes mellitus and coronary artery disease among urban and migrant Asian Indians, despite the absence of traditional risk factors. Evidence exists that Asian Indians are more insulin resistant than white persons and that insulin resistance may play an important role in the pathogenesis of these diseases. Increased visceral fat in Asian Indians is associated with increased generalized obesity, which is not apparent from their nonobese body mass index. Increased visceral fat is related to dyslipidemia and increased frequency of insulin resistance and may account for the increased prevalence of diabetes mellitus and cardiovascular disease in Asian Indians. In addition, early protein energy deprivation, as indicated by low weight at birth and at 1 year of age, may induce a state of vulnerability to the development of type 2 diabetes in later life, especially if the quantitative and qualitative aspects of nutrition and altered lifestyles during adult years pose an additional challenge.