A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
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DOI：
10.1101/gad.1927310
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发表时间：
2010-05-01
影响因子：
10.5
通讯作者：
Zhu, Jian-Kang
中科院分区：
文献类型：
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作者：
Jin, Hailing;Zhu, Jian-Kang
RNA病毒特别容易受到宿主中基于RNA的防御，因此进化出了特定的蛋白质，称为RNA沉默的病毒抑制因子（VSRs），作为反击。在这一期的《基因与发育》杂志上，Azevedo和他的同事（第904-915页）发现，萝卜皱缩病毒的VSR P38利用其甘氨酸/色氨酸（GW）基序作为ARGONAUTE （AGO）钩，吸引并解除宿主RNA沉默的基本效应。几种含有GW基序的细胞蛋白是酵母、植物和动物中RNA沉默效应复合物中AGOs的重要伙伴。GW基序似乎是调节RNA沉默途径活性的一种通用而有效的工具，使用GW模仿来竞争和抑制宿主的AGOs可能是许多病原体用来抵消宿主基于RNA的防御的一种策略。
RNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses.