The prognosis for patients with osteosarcoma who have received prior manipulative therapy
The prognosis for patients with osteosarcoma who have received prior manipulative therapy
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DOI：
10.1302/0301-620x.92b11.24706
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Chen, T. -H.
中科院分区：
文献类型：
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作者：
Wu, P. -K.;Chen, W. -M.;Chen, T. -H.
我们评估了骨肉瘤患者的长期预后，这些患者之前接受过手法治疗，这是一种在亚洲流行的治疗方法，并研究了其对几个预后因素的影响。在本研究的134例患者中，70例（52%）患者接受了手法治疗，64例（48%）患者未接受手法治疗。年龄、位置和肿瘤大小在两组之间没有显著差异。在有和没有手法治疗的组中，5年总生存率分别为58%和92%（p = 0.004）。手术组的原发性肺转移率和总肺转移率均显著较高（原发性：32% vs 3%，p = 0.003;总肺转移率：51.4% vs 18.8%，p < 0.001）。与未接受手法治疗的患者相比，接受手法治疗的患者局部复发率更高（29% vs 6%，p = 0.011）。有手法治疗的骨肉瘤患者的预后明显差于那些没有。手法治疗是生存的一个独立因素，这种形式的治疗可能会加速肿瘤细胞的扩散，因此必须避免，以改善骨肉瘤患者的预后。
We evaluated the long-term outcome of patients with an osteosarcoma who had undergone prior manipulative therapy, a popular treatment in Asia, and investigated its effects on several prognostic factors. Of the 134 patients in this study, 70 (52%) patients had manipulative therapy and 64 (48%) did not. The age, location, and size of tumour were not significantly different between the groups. The five-year overall survival rate was 58% and 92% in the groups with and without manipulative therapy (p = 0.004). Both the primary and overall rates of lung metastasis were significantly higher in the manipulative group (primary: 32% vs 3%, p = 0.003; overall lung metastasis rate: 51.4% vs 18.8%, p < 0.001). Patients who had manipulative therapy had higher local recurrence rates in comparison to patients who did not (29% vs 6%, p = 0.011). The prognosis for patients with osteosarcoma who had manipulative therapy was significantly poorer than those who had not. Manipulative therapy was an independent factor for survival.This form of therapy may serve as a mechanism to accelerate the spread of tumour cells, and therefore must be avoided in order to improve the outcome for patients with an osteosarcoma.