Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey
Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey
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DOI：
10.1186/1471-2377-9-48
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发表时间：
2009-08-26
期刊：
影响因子：
2.6
通讯作者：
Stewart, Robert
中科院分区：
文献类型：
--
作者：
Luisa Sosa, Ana;Albanese, Emiliano;Stewart, Robert
背景：1) 按年龄、性别和教育水平报告 10/66 痴呆研究组认知测试组四个组成部分的特定地点规范值； 2）按地点估计年龄、性别和教育水平的主要影响和交互影响； 3) 按地区和农村或城市位置调查选址的影响。方法：在古巴、多米尼加共和国、委内瑞拉、秘鲁、墨西哥、中国和印度进行了基于人口的横断面一阶段流域调查。该协议包括管理痴呆症社区筛查工具（CSI“D”，生成全球功能的 COGSCORE 衡量标准），以及建立阿尔茨海默氏病登记协会（CERAD）言语流利性（VF）、单词列表记忆（WLM，立即回忆）和回忆（WLR，延迟回忆）测试。分析中只包括那些没有痴呆症的人。结果：老年人和受教育程度较低的人在所有四项测试中表现较差。性的影响要小得多，而且不太一致。考虑到年龄、教育程度和性别的构成差异后，地点产生了相当大的影响。这在很大程度上是由地区影响造成的，与拉丁美洲的参与者相比，中国参与者的表现更好，而印度参与者的表现更差。区域对VF和WLM的影响比对COGSCORE和WLR更显着。结论：认知评估是痴呆诊断的基本要素。为此目的需要针对年龄和教育的规范，而性别的影响可能可以忽略不计。人们对文化影响的基础知之甚少，但我们的研究结果强调，规范数据可能无法安全地从一个群体推广到具有完全不同特征的另一个群体。就 10/66 痴呆症诊断的跨文化有效性而言，区域对 COGSCORE 和 WLR 的影响极小，这令人放心，该诊断仅使用 10/66 电池的这些元素。
Background: 1) To report site-specific normative values by age, sex and educational level for four components of the 10/66 Dementia Research Group cognitive test battery; 2) to estimate the main and interactive effects of age, sex, and educational level by site; and 3) to investigate the effect of site by region and by rural or urban location.Methods: Population-based cross-sectional one phase catchment area surveys were conducted in Cuba, Dominican Republic, Venezuela, Peru, Mexico, China and India. The protocol included the administration of the Community Screening Instrument for Dementia (CSI 'D', generating the COGSCORE measure of global function), and the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) verbal fluency (VF), word list memory (WLM, immediate recall) and recall (WLR, delayed recall) tests. Only those free of dementia were included in the analysis.Results: Older people, and those with less education performed worse on all four tests. The effect of sex was much smaller and less consistent. There was a considerable effect of site after accounting for compositional differences in age, education and sex. Much of this was accounted for by the effect of region with Chinese participants performing better, and Indian participants worse, than those from Latin America. The effect of region was more prominent for VF and WLM than for COGSCORE and WLR.Conclusion: Cognitive assessment is a basic element for dementia diagnosis. Age- and education-specific norms are required for this purpose, while the effect of gender can probably be ignored. The basis of cultural effects is poorly understood, but our findings serve to emphasise that normative data may not be safely generalised from one population to another with quite different characteristics. The minimal effects of region on COGSCORE and WLR are reassuring with respect to the cross-cultural validity of the 10/66 dementia diagnosis, which uses only these elements of the 10/66 battery.