Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions
Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions
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DOI：
10.1017/s002966511900106x
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发表时间：
2020-05-01
影响因子：
7
通讯作者：
Gibbons, Helena
中科院分区：
文献类型：
--
作者：
Brennan, Lorraine;Gibbons, Helena
生物体液的代谢组学特征可以通过饮食摄入、运动和疾病过程来改变，因此为许多生理过程的研究提供了重要工具。然而，除了疾病引起的干扰外，尿液和血浆的代谢组学特征也被证明会因许多内在的生理因素（例如年龄、性别、激素状态和昼夜变化）而发生变化。表征人体生物体液代谢组学谱中这种正常程度的变异是开发用于营养相关研究的代谢组学的必要且重要的一步。当前的综述重点关注性别对代谢组学特征的影响。许多研究报告称，性别会影响氨基酸、脂质、糖和酮酸等代谢物。此外，我们还研究了月经周期对代谢组学特征的影响。性别之间对饮食干预的反应也可能不同，强调这一点对于精准营养领域的发展非常重要。
The metabolomic profile of a biofluid can be altered by dietary intake, exercise and disease processes and, thus provides an important tool for the study of many physiological processes. However, in addition to perturbation due to disease, the metabolomic profile of urine and plasma has also been shown to vary due to many intrinsic physiological factors such as age, sex, hormonal status and diurnal variation. Characterisation of this normal degree of variation in the metabolomic profiles of human biofluids is a necessary and important step in the development of metabolomics for use in nutrition-related research. The current review focuses on the impact of sex on the metabolomic profile. A number of studies have reported that sex impacts metabolites such as amino acids, lipids, sugars and keto acids. Furthermore, we examine the effect of the menstrual cycle on the metabolomic profile. Responses to dietary interventions can also differ between the sexes and highlighting this is important for the development of the field of precision nutrition.