Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities
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DOI：
10.1016/j.bmcl.2006.05.081
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发表时间：
2006-08-15
影响因子：
2.7
通讯作者：
Zhou, Shi-ning
中科院分区：
文献类型：
--
作者：
Yang, Rui-yun;Lia, Chun-yuan;Zhou, Shi-ning
从褐藻内生真菌的菌丝体提取物中分离出两种新代谢物，名为 6-oxo-de-O-methyllasiodiplodin (1) 和 (E)-9-etheno-lasiodiplodin (2)，以及三种已知化合物 lasiodiplodin (3)、de-O-methyllasiodiplodin (4) 和 5-羟基-de-O-methyllasiodiplodin (5) （编号ZZF36）获自南海。使用光谱方法（主要是一维和二维核磁共振）阐明了它们的结构。另外，通过单晶X射线衍射分析确认了化合物1的结构。首次测试了lasiodiplodins及其13-乙酰基和12,14-二溴衍生物的抗菌活性，并对结果进行了相互比较。 (c) 2006 Elsevier Ltd. 保留所有权利。
Two new metabolites named 6-oxo-de-O-methyllasiodiplodin (1) and (E)-9-etheno-lasiodiplodin (2), with three known compounds lasiodiplodin (3), de-O-methyllasiodiplodin (4), and 5-hydroxy-de-O-methyllasiodiplodin (5), were isolated from the mycelium extracts of a brown alga endophytic fungus (No. ZZF36) obtained from the South China Sea. Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. Additionally, the structure of compound 1 was confirmed by single crystal X-ray diffraction analysis. The antimicrobial activities of lasiodiplodins, and the 13-acetyl and 12,14-dibromo derivatives of lasiodiplodin were tested for the first time and the results were compared to each other. (c) 2006 Elsevier Ltd. All rights reserved.