SCRAPIE PRODUCED EXPERIMENTALLY IN GOATS WITH SPECIAL REFERENCE TO CLINICAL SYNDROME
SCRAPIE PRODUCED EXPERIMENTALLY IN GOATS WITH SPECIAL REFERENCE TO CLINICAL SYNDROME
复制标题
DOI：
10.1016/s0368-1742(61)80013-1
复制
发表时间：
1961-01-01
期刊：
影响因子：
--
通讯作者：
MILLSON, GC
中科院分区：
文献类型：
--
作者：
PATTISON, IH;MILLSON, GC
I. 记录了对实验产生的瘙痒病的山羊的进一步临床观察，并对两种临床综合征——紧张和抓伤——进行了评论，这两种症状似乎可以通过脑内接种重现。有人认为，瘙痒症病原体的某些“菌株”会产生神经症状，而另一些则会引起抓挠综合症。快速冷冻和解冻瘙痒症山羊大脑的盐悬浮液不会对传染性产生不利影响。通过对山羊进行脑内接种，表明瘙痒症山羊大脑的乙醚提取物含有引起瘙痒症的病原体，而同一大脑的丙酮提取物在接种时不会产生这种疾病。 将其脑内接种到已观察两年的山羊中。
I. Further clinical observations on goats with experimentally-produced scrapie are recorded, and comment is made on two clinical syndromes-nervous and scratching- that appear to be reproducible by intracerebral inoculation. It is suggested that certain "strains" of the scrapie agent produce the nervous and others the scratching syndrome.Rapid freezing and thawing of a saline suspension of scrapie goat brain did not adversely affect the infectivity.An ether extract of scrapie goat brain was shown by intracerebral inoculation of goats to contain the scrapie-producing agent, while an acetone extract of the same brain failed to produce the disease when inoculated intra-cerebrally into goats that have been kept under observation for two years.