Glucocorticoid excess and hypertension
Glucocorticoid excess and hypertension
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DOI：
10.1007/s11906-004-0046-0
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发表时间：
2004-12-01
影响因子：
5.6
通讯作者：
Nieman, LK
中科院分区：
文献类型：
--
作者：
Baid, S;Nieman, LK
库欣综合征是一种罕见疾病，其特征是长期过量糖皮质激素暴露。高血压是该疾病最具区别性的特征之一，因为 80% 的患者都有高血压。库欣综合征患者的死亡率是普通人群的四倍，很可能是由于包括高血压在内的心血管危险因素数量增加所致。在本文中，我们回顾了糖皮质激素诱发的高血压的几种发病机制，包括钠/水和盐皮质激素过量的作用，以及脉管系统和肾脏的参与。尽管现有的抗高血压药物治疗高血压仅取得一定成功，但在库欣综合征治愈后，约30%的患者仍患有持续性高血压。
Cushing syndrome is a rare disorder characterized by chronic, excess glucocorticoid exposure. Hypertension is one of the most discriminating features of the disease, as it is present in 80% of patients. Patients with Cushing's syndrome have a morality rate four times that of the general population, most likely secondary to an increased number of cardiovascular risk factors, including hypertension. In this article, we review several pathogenetic mechanisms of glucocorticoid-induced hypertension, including the role of sodium/water and mineralocorticoid excess, as well as involvement of the vasculature and kidney. Although treatment of hypertension with available antihypertensive medications is only moderately successful, after cure of Cushing's syndrome, approximately 30% of patients have persistent hypertension.