A diet rich in high-oleic-acid sunflower oil favorably alters low-density lipoprotein cholesterol, triglycerides, and factor VII coagulant activity
A diet rich in high-oleic-acid sunflower oil favorably alters low-density lipoprotein cholesterol, triglycerides, and factor VII coagulant activity
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DOI：
10.1016/j.jada.2005.04.008
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发表时间：
2005-07-01
影响因子：
--
通讯作者：
Petocz, P
中科院分区：
文献类型：
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作者：
Allman-Farinelli, MA;Gomes, K;Petocz, P
目的比较高饱和脂肪饮食和单一不饱和脂肪饮食对血浆凝血因子VIIC、纤维蛋白原、纤溶酶原激活物抑制物-1和血脂的影响。研究设计为ABB/BAA超期交叉试验。其中一组饮食富含饱和脂肪酸(SFA)，脂肪占总能量的20.8%，连续5周，另一组富含单不饱和脂肪酸(MUFA)，脂肪占总能量的20.3%，持续10周。另一组先食用MUFA饮食5周，然后再食用SFA饮食10周。受试者/背景35~69岁的男性和女性均为非吸烟者，无慢性病且未服用任何药物。共招募18名受试者，其中15人(男5人，女10人)完成社区研究。干预措施在每个5周饮食周期开始和结束时采集血样，分析凝血和纤溶因子及血脂。受试者在三个节食期中各记两次为期3天的饮食日记，并在每次来访时称重以进行血液采集。主要指标包括空腹因子VIIC、纤维蛋白原、纤溶酶原激活物抑制物-1、胰岛素、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A-1和B，以及血浆油酸水平。统计分析采用考虑ABB/BAA超期交叉的一般线性模型。与SFA饮食相比，MUFA饮食的低密度脂蛋白胆固醇(P<；.001)和甘油三酯(P<；.01)水平较低。MUFA膳食中血浆磷脂和中性脂油酸(P<；.0001)均显著升高。结论用高油酸葵花籽油和人造黄油替代饱和脂肪含量高的食物对血脂和VIIC因子有良好的效果。这种油是多不饱和脂肪酸的另一个有用来源，可用于预防心脏病的饮食。
Objective To compare concentrations of factor VII coagulant activity (factor VIIc), fibrinogen, plasminogen activator inhibitor-1, and blood lipids on a saturated fat-rich diet with one rich in monounsaturated fat.Design Subjects were randomly allocated to two groups. The study design was an ABB/BAA extra-period crossover. One group consumed a diet rich in saturated fatty acid (SFA) with fat making up 20.8% of total energy, for 5 weeks and then one rich in monounsaturated fatty acid (MUFA), with fat making up 20.3% of total energy for 10 weeks. The other group consumed the MUFA diet for 5 weeks followed by the SFA diet for 10 weeks.Subjects/setting Men and women aged 35 to 69 years who were nonsmokers with no chronic illness and not on any medication were recruited to participate. Eighteen subjects were recruited and 15 (5 men, 10 women) completed the community-based study.Intervention Blood was sampled at the beginning and end point of each 5-week diet period for analysis of coagulation and fibrinolysis factors and blood lipids. Subjects kept 3-day food diaries twice during each of the three diet periods and were weighed on each visit for blood collection. Analysis of plasma fatty acids was used to indicate dietary compliance.Main outcome measures Differences in fasting factor VIIc, fibrinogen, plasminogen activator inhibitor-1, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B, and plasma oleic acid levels while receiving the SFA diet vs MUFA diet.Statistical analysis A general linear model allowing for the ABB/BAA extra-period crossover, was used for each of the outcome measures.Results Factor VIIc was lower on the MUFA diet (P < .05) but fibrinogen and insulin concentrations and plasminogen activator inhibitor-1 activity did not differ between diets. Low-density lipoprotein cholesterol (P < .001) and triglyceride (P < .01) levels were lower on the MUFA diet compared with the SFA diet. A significant increase in both plasma phospholipid and neutral lipid oleic acid (P < .0001) occurred on the MUFA diet.Conclusions Substitution of foods rich in saturated fat with foods rich in high-oleic-acid sunflower oil and margarine has favorable outcomes on blood lipids and factor VIIc. This oil presents another useful source of MUFA for diets aimed at prevention of heart disease.