TMPRSS2-ERG fusion prostate cancer:: An early molecular event associated with invasion
TMPRSS2-ERG fusion prostate cancer:: An early molecular event associated with invasion
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DOI：
10.1097/01.pas.0000213424.38503.aa
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发表时间：
2007-06-01
影响因子：
5.6
通讯作者：
Rubin, Mark A.
中科院分区：
文献类型：
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作者：
Perner, Sven;Mosquera, Juan-Miguel;Rubin, Mark A.
前列腺癌（PCA）是西方世界最常见的癌症之一，也是导致发病和死亡的主要原因。 TMPRSS2-ERG 融合最近被确定为这种恶性肿瘤中常见的复发性染色体畸变。在我们的研究中，我们询问了广泛的良性、前体和恶性前列腺病变，以使用多色间期荧光原位杂交测定来评估 TMPRSS2-ERG 融合状态。来自医院队列的样本包括 237 个临床局部 PCA、34 个激素初治转移、9 个激素难治性转移、26 个高级前列腺上皮内瘤变病变、15 个良性前列腺增生样本、38 个增生性炎症萎缩样本和 47 个良性前列腺组织样本。 TMPRSS2-ERG 融合存在于 48.5% 的临床局部 PCA、30% 的激素初治转移、33% 的激素难治性转移以及 19% 的与癌灶混合的高级前列腺上皮内瘤变病变中。几乎所有这些融合阳性病例都显示出融合模式的均匀分布。相比之下，其他样本均不存在这种遗传畸变。如果我们考虑到 PCA 的高发病率和该基因融合的高频率，TMPRSS2-ERG 是迄今为止在人类恶性肿瘤中描述的最常见的遗传畸变。此外，由于其高度特异性，其作为生物标志物和辅助诊断测试的临床应用前景广阔。
Prostate cancer (PCA) is one of the most prevalent cancers and a major leading cause of morbidity and mortality in the Western world. The TMPRSS2-ERG fusion was recently identified as a common recurrent chromosomal aberration in this malignancy. In our study, we interrogated a broad spectrum of benign, precursor, and malignant prostatic lesions to assess the TMPRSS2-ERG fusion status using a multicolor interphase fluorescence in situ hybridization assay. Samples from hospital-based cohorts consisted of 237 clinically localized PCA, 34 hormone naive metastases, 9 hormone refractory metastases, 26 high grade prostatic intraepithelial neoplasia lesions, 15 samples of benign prostatic hyperplasia, 38 of proliferative inflammatory atrophy, and 47 of benign prostatic tissue. The TMPRSS2-ERG fusion was present in 48.5% of clinically localized PCA, 30% of hormone naive metastases, 33% of hormone refractory metastases, and in 19% of high grade prostatic intraepithelial neoplasia lesions in intermingling to cancer foci. Almost all these fusion positive cases show a homogenous distribution of the fusion pattern. In contrast, none of the other samples harbored this genetic aberration. If we consider the high incidence of PCA and the high frequency of this gene fusion, TMPRSS2-ERG is the most common genetic aberration so far described in human malignancies. Furthermore, its clinical application as a biomarker and ancillary diagnostic test is promising given its high specificity.