ANTIGENIC REQUIREMENTS FOR TRIGGERING OF CYTOTOXIC T LYMPHOCYTES
ANTIGENIC REQUIREMENTS FOR TRIGGERING OF CYTOTOXIC T LYMPHOCYTES
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DOI：
10.1111/j.1600-065x.1977.tb00236.x
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发表时间：
1977-01-01
影响因子：
8.7
通讯作者：
BACH, ML
中科院分区：
文献类型：
--
作者：
BACH, FH;GRILLOTCOURVALIN, C;BACH, ML
The cotnplexity of T lymphocyte subclasses that respond to alloantigens can be analyzed from at least two perspectives: first, by identification and separation of the different subclasses on the basis of their adherence properties, differentiation antigens present on their surface or other characteristics; and second, by analyzing the alloantigenic systems to which the cells respond. We have focused primarily on the second of these approaches utilizing genetically-defined antigens of the major histocompatibility complex (MHC) as the stimulating factors evoking T lymphocyte responses. It is from this perspective that we shall analyze the requirements for the triggering of T lymphocytes, discussing the cytotoxic T lymphocyte (CTL) in detail with attendant comments about helper and suppressor T lymphocytes. We have used a number of different test systems that appear to provide information in this regard; four of these will be discussed. First, the in vitro generation of helper, suppressor and cytotoxic T lymphocytes in a primary mixed lymphocyte culture (MLC) sensitization system; second, secondary
