Genotype-phenotype associations between chymase and angiotensin - converting enzyme gene polymorphisms in chronic systolic heart failure patients
Genotype-phenotype associations between chymase and angiotensin - converting enzyme gene polymorphisms in chronic systolic heart failure patients
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DOI：
10.1097/gim.0b013e3181804b9c
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发表时间：
2008-08-01
影响因子：
8.8
通讯作者：
Lewis, Basil S.
中科院分区：
文献类型：
--
作者：
Amir, Ruthie E.;Amir, Offer;Lewis, Basil S.
目的：血管紧张素11是通过血管紧张素转换酶和溶酶途径产生的，在心力衰竭的心肌重构过程中起着至关重要的作用。我们研究了血管紧张素转换酶和乳糜酶-1在收缩期心力衰竭患者中的多态性及其与临床状态和左心室功能的关系。方法：对195例心力衰竭和收缩期左心室功能障碍（射血分数）患者进行基因分型
Purpose: Angiotensin 11, which plays a crucial role in the myocardial remodeling process of heart failure, is generated via the angiotensin-converting enzyme and chymase pathways. We studied angiotensin-converting enzyme and chymase-1 polymorphisms in patients with systolic heart failure and the correlation with clinical status and left ventricular function. Methods: We genotyped 195 patients with heart failure and systolic left ventricular dysfunction (ejection fraction