Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
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DOI:
10.1289/ehp.5760
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发表时间:
2003-08
影响因子:
10.4
通讯作者:
Worth AP
Worth AP
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Cronin MT;Jaworska JS;Walker JD;Comber MH;Watts CD;Worth AP

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本文综述了监管机构和权威机构使用定量(和定性)结构-活性关系(QSARs和SARs)来预测急性毒性、诱变性、致癌性和其他健康影响的情况。一些SAR和QSAR申请,由监管机构和当局进行审查。这些包括使用简单的QSAR分析,以及使用多变量QSAR,以及许多不同的专家系统方法。
This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
DOI: 10.1002/qsar.19950140402
发表时间: 1995-08-01
期刊: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
影响因子: --
作者:
Cronin, MTD;Dearden, JC
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DOI: 10.1289/ehp.5759
发表时间: 2003-08
影响因子: 10.4
作者:
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通讯作者: Worth AP
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