Bioimpedance-Derived Phase Angle and Mortality Among Older People
Bioimpedance-Derived Phase Angle and Mortality Among Older People
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DOI：
10.1089/rej.2016.1879
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发表时间：
2017-04-01
影响因子：
2.6
通讯作者：
Graf, Christophe E.
中科院分区：
文献类型：
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作者：
Genton, Laurence;Norman, Kristina;Graf, Christophe E.
工作背景：通过生物电阻抗分析（BIA）测量的相位角可能是健康状态的标志。目的：前瞻性收集的BIA测量值的历史队列研究旨在调查相位角与老年人死亡率之间的联系，并评估是否可以定义相位角截止值。设计：我们纳入了在日内瓦大学医院使用Nutriguard（R）设备进行BIA测量的所有年龄≥ 65岁的成年人。我们回顾性检索了2012年12月之前最后一次BIA测量时的相位角和合并症以及死亡率。我们使用相同品牌的BIA设备确定的参考值，计算针对性别、年龄和体重指数（BMI）标准化的相位角。将性别特异性和标准化相位角分类为四分位数。通过单变量和多变量考克斯回归模型，KaplanMeier曲线和受试者工作特征（ROC）curves.Results：我们纳入了1307（38%女性）参与者，其中628（44%女性）死亡的死亡率与性别特异性或标准化相位角的关联进行了评估。在校正合并症和测量设置的多变量考克斯回归模型中（门诊与住院），随着标准化相位角四分位数的增加，（HR 0.71 [95% CI 0.58，0.86]、0.53 [95% CI 0.42，0.67]和0.32 [95% CI 0.23，0.43]）。连续标准化相位角的判别值，评估为ROC曲线下面积，为0.72（95%CI 0.70，0.75）。我们不能定义一个可接受的相位角截止个别预测死亡率（LK）的敏感性和特异性values.Conclusions的基础上：本研究显示的关联相位角和老年患者的死亡率，独立于年龄，性别，合并症，BMI类别和设置的测量。
Background: Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state.Objective: This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined.Design: We included all adults aged >= 65 years who underwent a BIA measurement by the Nutriguard (R) device at the Geneva University Hospitals. We retrieved retrospectively the phase angle and comorbidities at the last BIA measurement and mortality until December 2012. We calculated phase angle standardized for sex, age, and body mass index (BMI), using reference values determined with the same brand of BIA device. Sex-specific and standardized phase angle were categorized into quartiles. The association of mortality with sex-specific or standardized phase angle was evaluated through univariate and multivariate Cox regression models, KaplanMeier curves, and receiver operating characteristic (ROC) curves.Results: We included 1307 (38% women) participants, among whom 628 (44% women) died. In a multivariate Cox regression model adjusted for comorbidities and setting of measurement (ambulatory vs. hospitalized), the protective effect against mortality increased progressively as the standardized phase angle quartile increased (HR 0.71 [95% CI 0.58, 0.86], 0.53 [95% CI 0.42, 0.67], and 0.32 [95% CI 0.23, 0.43]). The discriminative value of continuous standardized phase angle, assessed as the area under the ROC curve, was 0.72 (95% CI 0.70, 0.75). We could not define an acceptable phase angle cutoff for individual prediction of mortality (LK), based on sensibility and specificity values.Conclusions: This study shows the association of phase angle and mortality in older patients, independent of age, sex, comorbidities, BMI categories, and setting of measurement.