Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease
Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease
复制标题
DOI：
10.1016/j.micinf.2011.06.002
复制
发表时间：
2011-11-01
影响因子：
5.8
通讯作者：
Tanowitz, Herbert B.
中科院分区：
文献类型：
--
作者：
Matos Ferreira, Adaliene Versiani;Segatto, Marcela;Tanowitz, Herbert B.
克氏锥虫是南美锥虫病的病因，在受感染的实验动物和人类的组织中持续存在。在这里，我们证明了持久性的寄生虫在脂肪组织从三个10老年血清阳性慢性心脏病患者。9名对照组患者的脂肪中没有寄生虫。我们还表明，T cruzi寄生在体外的初级脂肪细胞。因此，在人类和小鼠中，寄生虫可以在脂肪组织中持续数十年，并成为感染的宿主。(C)2011年巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.