Disparities in genetics assessment for women with ovarian cancer: Can we do better?
Disparities in genetics assessment for women with ovarian cancer: Can we do better?
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DOI：
10.1016/j.ygyno.2017.10.034
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发表时间：
2018-04-01
影响因子：
4.7
通讯作者：
Chen, Lee-may
中科院分区：
文献类型：
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作者：
Manrriquez, Erica;Chapman, Jocelyn S.;Chen, Lee-may
客观的。我们试图描述卵巢癌女性遗传咨询的转诊模式，并假设转诊率和检测率的差异是由社会经济因素决定的。方法。 2012年8月至2016年1月的病理报告中包含“浆液性”或“卵巢性”字样，从而确定了患者。患者信息通过电子病历获得。主要结果是进行遗传学转诊和完成咨询。次要结果是完成基因测试。结果。我们确定了 246 名被诊断患有卵巢癌的女性。十人之前曾接受过咨询并被排除在外。 53% 的患者转诊接受咨询，从诊断到咨询的平均时间为 4.6 个月。年龄和家族史与转诊无关，但转诊率因种族而异，白种人女性转诊率为 61%，亚裔、拉丁裔和黑人女性分别为 40%、38% 和 33%（p = 0.035）。总体而言，36% 的确诊患者接受了咨询，33% 的患者接受了检测。英语 (p < 0.0001)，高级浆液组织学 (p =
Objective. We sought to characterize referral patterns for genetic counseling for women with ovarian cancer and hypothesized that differences in referral and testing rates are shaped by socioeconomic factors.Methods. Patients were identified by pathology reports from August 2012 to January 2016 containing the words "serous" or "ovarian." Patient information was obtained via electronic medical record. Primary outcomes were placement of a genetics referral and completion of counseling. A secondary outcome was completion of genetic testing.Results. We identified 246 women with a diagnosis of ovarian cancer. Ten were previously counseled and excluded. 53% of patients were referred for counseling with mean time from diagnosis to counseling of 4.6 months. Age and family history were not associated with referral, however rates differed by race with 61% of Caucasian and 40%, 38% and 33% of Asian, Latina and Black women, respectively, referred (p = 0.035). Overall, 36% of patients diagnosed underwent counseling, and 33% were tested. English language (p < 0.0001), high-grade serous histology (p =