Toenail concentrations of trace elements and occupational history in pancreatic cancer
Toenail concentrations of trace elements and occupational history in pancreatic cancer
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DOI：
10.1016/j.envint.2019.03.037
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发表时间：
2019-06-01
影响因子：
11.8
通讯作者：
Porta, Miquel
中科院分区：
文献类型：
--
作者：
Camargo, Judit;Pumarega, Jose A.;Porta, Miquel
背景：一些潜在的接触镉、砷、铅、硒、镍和铬的职业与胰腺外分泌癌(EPC)的风险增加有关，但还没有研究评估这些化合物的体内浓度在职业暴露和非暴露的受试者中是否存在差异。没有研究发现接触此类金属会增加EPC的风险。目的：分析EPC患者趾甲中微量元素浓度与职业史的关系。方法：对114例EPC患者进行个人访谈，了解其职业史和生活方式因素。职业是根据1988年国际标准职业分类进行编码的。由两名工业卫生员和芬兰职业暴露矩阵(FINJEM)对选定的职业暴露进行评估。采用电感耦合等离子体质谱仪测定了趾甲样品中12种微量元素的含量。结果：职业性接触芳烃溶剂(AHS)的患者体内镉、锰、铅、铁、钒等元素含量较高。接触任何农药者的镉浓度均值为0.056微克/克[95%可信区间：0.029-0.108]，非接触者镉浓度均值为0.023微克/克[0.017-0.031]。职业性接触杀虫剂的患者镉和锰浓度较高。较高的钒、铅和砷浓度与甲醛暴露有关。接触氯代烃溶剂与钒、铅有关，接触多环芳烃(PAHs)与砷有关。结论：职业性接触AHS、农药、氯代烃溶剂、甲醛、挥发性硫化物和多环芳烃(PAHs)患者体内多种金属含量较高。这些因素可能解释了以前报告的胰腺癌的一些职业风险。
Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have assessed whether body concentrations of such compounds differed among subjects occupationally exposed and unexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether past occupations were the source of exposure.Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupational history in EPC patients.Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors. Occupations were coded according to the International Standard Classification of Occupations 1988. Selected occupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix (Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated.Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations of cadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to any pesticide was 0.056 mu g/g [95% CI: 0.029-0.108], and, for unexposed cases, 0.023 mu g/g [0.017-0.031]. Patients occupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrations of vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead were also associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure to polycyclic aromatic hydrocarbons (PAHs).Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde, volatile sulphur compounds and PAHs had higher concentrations of several metals. These elements may account for some of the occupational risks previously reported for pancreatic cancer.