Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study
Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study
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DOI：
10.1016/j.sleep.2019.08.021
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发表时间：
2020-04-01
期刊：
影响因子：
4.8
通讯作者：
Gershon, Andrea S.
中科院分区：
文献类型：
--
作者：
Kendzerska, Tetyana;Leung, Richard S.;Gershon, Andrea S.
目的/背景：关于阻塞性睡眠呼吸暂停（OSA）与心血管结局之间存在性别差异的证据有限且存在争议。我们进行了一项历史队列研究，以调查这种关系。患者/方法：临床数据的成年人进行睡眠研究，在一个大型城市学术医院（多伦多，加拿大）1994年至2010年之间的省级卫生行政数据从1991年至2015年。我们拟合了考克斯回归模型来研究OSA严重程度与心血管复合结局（全因死亡率或因心肌梗死、中风、心力衰竭或房颤住院）之间的相关性，控制了风险因素并按性别分层。在平均9.3年的时间里，1782名（18%）参与者产生了结果。睡眠时间百分比与血氧饱和度之间的关系
Objective/Background: Evidence on sex differences in the association between obstructive sleep apnea (OSA) and cardiovascular outcomes is limited and controversial. We conducted a historical cohort study to investigate this relationship.Patients/methods: Clinical data on adults who underwent sleep study at a large urban academic hospital (Toronto, Canada) between 1994 and 2010 were linked to provincial health administrative data from 1991 to 2015. We fit Cox regressions to investigate the association between OSA severity and a cardiovascular composite outcome (all-cause mortality or hospitalization due to myocardial infarction, stroke, heart failure or atrial fibrillation), controlling for risk factors and stratifying by sex.Results: A total of 10,149 subjects were included: median age of 49 years, 38% women. Over a median of 9.3 years, 1782 (18%) participants developed an outcome. The association between percentage of sleep time spent with oxygen saturation