Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#
Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#
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DOI：
10.1080/14786419.2015.1062762
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发表时间：
2016-04-02
影响因子：
2.2
通讯作者：
Liu, Lan
中科院分区：
文献类型：
--
作者：
Li, Jing;Xue, Yanyu;Liu, Lan
四种新的毛二倍体蛋白 (1-4) 以及三种已知的类似物已从红树林内生真菌毛毛二倍体 sp. 中分离出来。 318#。通过光谱技术阐明了它们的结构。在体外评估了化合物1-7针对人类癌细胞系THP1、MDA-MB-435、A549、HepG2和HCT-116的细胞毒活性。化合物4表现出中等的细胞毒活性。
Four new lasiodiplodins (1-4), together with three known analogues, have been isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds 1-7 were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound 4 exhibited moderate cytotoxic activities.