Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis.
Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis.
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DOI：
10.1155/2016/4285215
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发表时间：
2016
影响因子：
4.3
通讯作者：
Kozlowska U
中科院分区：
文献类型：
--
作者：
Klimczak A;Kozlowska U
多能间充质基质/干细胞（MSCs）存在于许多人体器官中，由具有自我更新能力的异质细胞群组成。这些细胞可以从不同的组织中分离出来，它们的形态、免疫表型和分化潜力取决于它们的来源组织。每个器官都含有特定的基质细胞群，维持其所在组织的再生过程，但其中一些基质细胞具有更广泛的可塑性，并分化成多细胞系。从成人组织中分离的间充质干细胞是组织再生和组织工程的理想候选者。然而，间充质干细胞不仅具有结构性的组织修复作用，还具有很强的免疫调节和抗炎特性，并可能通过调节局部环境影响组织修复。本文概述了组织常驻间充质间质细胞和祖细胞（来自骨髓、肝脏、骨骼肌、皮肤、心脏和肺）与组织再生和组织稳态相关的生物学知识。
Multipotent mesenchymal stromal/stem cells (MSCs) reside in many human organs and comprise heterogeneous population of cells with self-renewal ability. These cells can be isolated from different tissues, and their morphology, immunophenotype, and differentiation potential are dependent on their tissue of origin. Each organ contains specific population of stromal cells which maintain regeneration process of the tissue where they reside, but some of them have much more wide plasticity and differentiate into multiple cells lineage. MSCs isolated from adult human tissues are ideal candidates for tissue regeneration and tissue engineering. However, MSCs do not only contribute to structurally tissue repair but also MSC possess strong immunomodulatory and anti-inflammatory properties and may influence in tissue repair by modulation of local environment. This paper is presenting an overview of the current knowledge of biology of tissue-resident mesenchymal stromal and progenitor cells (originated from bone marrow, liver, skeletal muscle, skin, heart, and lung) associated with tissue regeneration and tissue homeostasis.