Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.
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DOI：
10.1126/science.1187029
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发表时间：
2010-09-17
期刊：
影响因子：
--
通讯作者：
Iwasaki A
中科院分区：
文献类型：
--
作者：
Sasai M;Linehan MM;Iwasaki A
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor κB (NF-κB)–dependent proinflammatory cytokines and interferon regulatory factor 7 (IRF7)–dependent type I interferons (IFNs). Recognition of viral nucleic acids by TLR9 requires its cleavage in the endolysosomal compartment. Here, we show that TLR9 signals leading to the activation of type I IFN, but not proinflammatory cytokine genes, require TLR9 trafficking from endosomes to a specialized lysosome-related organelle. Furthermore, we identify adapter protein-3 as the protein complex responsible for the trafficking of TLR9 to this subcellular compartment. Our results reveal an intracellular mechanism for bifurcation of TLR9 signals by selective receptor trafficking within the endosomal system.
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DOI：
10.1084/jem.20060401
发表时间：
2006-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guiducci C;Ott G;Chan JH;Damon E;Calacsan C;Matray T;Lee KD;Coffman RL;Barrat FJ
通讯作者：
Barrat FJ
DOI：
10.1084/jem.20091776
发表时间：
2010-04-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gotoh K;Tanaka Y;Nishikimi A;Nakamura R;Yamada H;Maeda N;Ishikawa T;Hoshino K;Uruno T;Cao Q;Higashi S;Kawaguchi Y;Enjoji M;Takayanagi R;Kaisho T;Yoshikai Y;Fukui Y
通讯作者：
Fukui Y
影响因子：
64.8
作者：
Honda, K;Ohba, Y;Taniguchi, T
通讯作者：
Taniguchi, T
影响因子：
64.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.0710351105
发表时间：
2008-02-26
影响因子：
11.1
作者：
Watarai, Hiroshi;Sekine, Etsuko;Taniguchi, Masaru
通讯作者：
Taniguchi, Masaru