A more complete, complexed and structured interactome
A more complete, complexed and structured interactome
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DOI：
10.1016/j.sbi.2007.05.011
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发表时间：
2007-06-01
影响因子：
6.8
通讯作者：
Russell, Robert B.
中科院分区：
文献类型：
--
作者：
Devos, Damien;Russell, Robert B.
多蛋白复合物在几乎所有重要的细胞过程中都起着关键作用。在过去的一年里，有几篇论文的发表，阐明了我们对这些分子机器的数量和组成的了解，使用了高通量的纯化方法。其他研究已经阐明了蛋白质相互作用、网络和分子组装的结构和功能方面。因此，我们对生命系统中有多少复合物、它们是什么样子以及它们在细胞中扮演的角色有了更完整的认识。
Multiprotein complexes are key players in virtually all important cellular processes. The past year has seen the publication of several papers that have illuminated what we know about the number and composition of these molecular machines, using high-throughput purification methods. Other studies have illuminated structural and functional aspects of protein interactions, networks and molecular assemblies. As a result, we have a more complete view of how many complexes are in living systems, what they look like and the roles they play in the cell.