CYCLIN-D AND ONCOGENESIS
CYCLIN-D AND ONCOGENESIS
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DOI：
10.1016/s0959-437x(05)80334-x
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发表时间：
1993-02-01
影响因子：
4
通讯作者：
ARNOLD, A
中科院分区：
文献类型：
--
作者：
MOTOKURA, T;ARNOLD, A
D型细胞周期蛋白是高等真核生物中可能调控G1-S期进程的候选“G1细胞周期蛋白”之一。人类细胞周期蛋白D1基因，也称为PRAD 1（以前称为D11 S287），是一种推定的原癌基因，与几种类型的人类肿瘤密切相关，包括甲状旁腺腺瘤，B细胞肿瘤（称为“BCL-1癌基因”），以及乳腺癌和鳞状细胞癌。细胞周期蛋白D1/PRAD 1以及其他D型细胞周期蛋白的失调产生导致肿瘤发展的机制才刚刚开始被破译。
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.