Internal exposure to pollutants and sexual maturation in Flemish adolescents
Internal exposure to pollutants and sexual maturation in Flemish adolescents
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DOI：
10.1038/jes.2010.2
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发表时间：
2011-05-01
影响因子：
4.5
通讯作者：
van Larebeke, Nicolas
中科院分区：
文献类型：
--
作者：
Den Hond, Elly;Dhooge, Willem;van Larebeke, Nicolas
弗兰德斯人口稠密，工业发达，农业集约化。研究了青少年（14-15岁）性成熟与体内接触污染物的关系。对1679名居住在研究地区的青少年进行了血清污染物和性激素水平的测定。性发育数据来自医学院考试档案。自我评估问卷提供了关于健康、药物使用和生活方式因素的信息。在男孩中，血清中六氯苯、p，p '-DDE和多氯联苯（标记物PCB 138、153和180的总和）的水平与青春期分期（阴毛和生殖器发育）显著正相关。较高水平的血清六氯苯和血铅分别与较低和较高的男性乳房发育症的风险。在女孩中，血铅和阴毛发育之间存在显著的负相关;多氯联苯的高暴露与月经初潮时间的延迟显著相关。环境中污染物的暴露水平达到佛兰芒人口的实际水平，对青春期发育产生可测量的影响。然而，需要进一步了解毒性作用模式和敏感的暴露窗口，以解释目前的研究结果。Journal of Exposure Science and Environmental Epidemiology（2011）21，224-233; doi：10.1038/jes.2010.2; 2010年3月3日在线发表
Flanders is densely populated with much industry and intensive farming. Sexual maturation of adolescents (aged 14-15 years) was studied in relation to internal exposure to pollutants. Serum levels of pollutants and sex hormones were measured in 1679 participants selected as a random sample of the adolescents residing in the study areas. Data on sexual development were obtained from the medical school examination files. Self-assessment questionnaires provided information on health, use of medication and lifestyle factors. In boys, serum levels of hexachlorobenzene (HCB), p,p'-DDE and polychlorinated biphenyls (sum of marker PCB138, 153 and 180) were significantly and positively associated with pubertal staging (pubic hair and genital development). Higher levels of serum HCB and blood lead were associated with, respectively, a lower and a higher risk of gynecomastia. In girls, significant and negative associations were detected between blood lead and pubic hair development; higher exposure to PCBs was significantly associated with a delay in timing of menarche. Environmental exposures to pollutants at levels actually present in the Flemish population are associated with measurable effects on pubertal development. However, further understanding of toxic mode of action and sensitive windows of exposure is needed to explain the current findings. Journal of Exposure Science and Environmental Epidemiology (2011) 21, 224-233; doi:10.1038/jes.2010.2; published online 3 March 2010