MetaCyc: a multiorganism database of metabolic pathways and enzymes
MetaCyc: a multiorganism database of metabolic pathways and enzymes
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DOI：
10.1093/nar/gkh100
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Karp, PD
中科院分区：
文献类型：
--
作者：
Krieger, CJ;Zhang, PF;Karp, PD
MetaCyc数据库（参见URL http://MetaCyc.org）是来自各种生物体（主要是微生物和植物）的代谢途径和酶的集合。MetaCyc的目标是包含每个实验阐明的途径的代表性样本，从而对代谢的宇宙进行编目。MetaCyc还描述了反应，化合物和基因。MetaCyc中的许多途径和酶包含广泛的信息，包括评论和文献引用。SRI的Pathway Tools软件支持MetaCyc的查询、可视化和管理。凭借其广泛的代谢信息的广度和深度，MetaCyc是各种应用的宝贵资源。MetaCyc是途径和酶的参考数据库，与SRI的代谢途径预测程序结合使用，创建途径/基因组数据库，可以通过科学文献的精选进行扩展并发布在万维网上。MetaCyc也是一个易于访问的微生物和植物途径的综合资源，用于基因组分析，基础研究，教育，代谢工程和系统生物学。在过去的2年中，用于查询、可视化和编辑MetaCyc的数据内容和Pathway Tools软件已经显著扩展。本文描述了这些增强功能。
The MetaCyc database (see URL http://MetaCyc.org) is a collection of metabolic pathways and enzymes from a wide variety of organisms, primarily microorganisms and plants. The goal of MetaCyc is to contain a representative sample of each experimentally elucidated pathway, and thereby to catalog the universe of metabolism. MetaCyc also describes reactions, chemical compounds and genes. Many of the pathways and enzymes in MetaCyc contain extensive information, including comments and literature citations. SRI's Pathway Tools software supports querying, visualization and curation of MetaCyc. With its wide breadth and depth of metabolic information, MetaCyc is a valuable resource for a variety of applications. MetaCyc is the reference database of pathways and enzymes that is used in conjunction with SRI's metabolic pathway prediction program to create Pathway/Genome Databases that can be augmented with curation from the scientific literature and published on the world wide web. MetaCyc also serves as a readily accessible comprehensive resource on microbial and plant pathways for genome analysis, basic research, education, metabolic engineering and systems biology. In the past 2 years the data content and the Pathway Tools software used to query, visualize and edit MetaCyc have been expanded Significantly. These enhancements are described in this paper.