Genes encoding T-cell antigens.
Genes encoding T-cell antigens.
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编码 T 细胞抗原的基因。
DOI：
10.1111/j.1749-6632.1988.tb21625.x
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发表时间：
1988
影响因子：
5.2
通讯作者：
Parnes,JR
中科院分区：
文献类型：
--
作者：
Parnes,JR
CD 8是由大多数胸腺细胞和成熟T淋巴细胞表达的细胞表面糖蛋白，其识别I类主要组织相容性复合体（MHC）分子。大多数CD 8细胞在功能上具有细胞毒性或抑制性。据推测，这种分子的功能是增加T细胞和靶细胞或抗原呈递之间相互作用的亲合力。最近的证据为这一观点提供了强有力的支持。[4]推测的CD 8配体是I类MHC分子的一个非多态性区域^，^-^，但迄今为止还没有直接证明这种结合。为了解释对CD 8特异的单克隆抗体（mAb）抑制由凝集素或抗CD 3 mAb诱导的T细胞活化的数据，已经替代地提出CD 8的功能可能是向T细胞递送负信号。然而，目前没有数据表明这种信号的传输。在这份报告中，我将回顾我们最近的一些研究的分子结构，表达和功能的CD 8。
CD8 is a cell surface glycoprotein expressed by most thymocytes and by mature T lymphocytes that recognize class I major histocompatibility complex (MHC) molecules. Most CD8 cells are cytotoxic or suppressor in function. It has been postulated that the function of this molecule is to increase the avidity of the interaction between T cells and target cells or antigen-presenting Recent evidence provides strong support for this notion. 4d The presumed ligand for CD8 is a nonpolymorphic region of class I MHC molecule^,^-^ but there has been no direct demonstration of such binding to date. To explain data in which monoclonal antibodies (mAbs) specific for CD8 inhibit T-cell activation induced by lectins or anti-CD3 mAbs, it has alternatively been suggested that the function of CD8 might be to deliver a negative signal to the T ell.^.^ However, there are currently no data to indicate transmission of such a signal. In this report I will review some of our recent studies of the molecular structure, expression, and function of CD8.