Selectivity enhancement of anion-responsive electrodes by pulsed chronopotentiometry
Selectivity enhancement of anion-responsive electrodes by pulsed chronopotentiometry
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DOI：
10.1016/j.aca.2006.09.042
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发表时间：
2007-01-30
影响因子：
6.2
通讯作者：
Bakker, Eric
中科院分区：
文献类型：
--
作者：
Gemene, Kebede L.;Shvarev, Alexey;Bakker, Eric
离子选择性电极的选择性得到了巨大而稳健的改进，用于测量丰富的离子。在脉冲计时电位测量模式下，在亲脂性离子高氯酸盐和水杨酸盐的稀释背景下测量的亲水性氯离子的选择性提高了两个数量级以上。这归因于在这种测量模式下对稀亲脂性离子的强大动力学区分，这在经典电位测定法中是不可能实现的。在引起电势显着变化之前，发现干扰离子的最大容许浓度约为 30 μM。作为一个实际相关的例子，证明了 72 μM 水杨酸盐（反映 1:10 稀释血液）中氯化物的稳健检测，检测限为 0.5 mM 氯化物。相应的电位传感器在这些条件下没有给出有用的氯化物响应。 (c) 2006 Elsevier B.V. 保留所有权利。
A large and robust selectivity improvement of ion-selective electrodes is presented for the measurement of abundant ions. An improvement in selectivity by more than two orders of magnitude has been attained for the hydrophilic chloride ions measured in a dilute background of the lipophilic ions perchlorate and salicylate in a pulsed chronopotentiometric measurement mode. This is attributed to a robust kinetic discrimination of the dilute lipophilic ions in this measuring mode, which is not possible to achieve in classical potentiometry. Maximum tolerable concentrations of the interfering ions are found to be on the order of 30 mu M before causing substantial changes in potential. As an example of practical relevance, the robust detection of chloride in 72 mu M salicylate (reflecting 1: 10 diluted blood) with a detection limit of 0.5 mM chloride is demonstrated. Corresponding potentiometric sensors did not give a useful chloride response under these conditions. (c) 2006 Elsevier B.V. All rights reserved.